Monthly Archives: October 2017

The famous fictional detective Sherlock Holmes stated, “It has long been an axiom of mine that the little things are infinitely the most important.” We are interested in how DNA is used to solve crimes and other mysteries. For example, … Continue reading →

Caffeine has a wide range of effects in the human body, including vasoconstriction, bronchodilation, and stimulation of fat breakdown. Despite its widespread use, caffeine affects individuals very differently. Some people drink coffee all day, even right before bed, while others … Continue reading →

Many anti-cancer agents work by binding to DNA. We have characterized DNA sites targeted by interstrand cross-linking agents and probed structural abnormalities induced by cross-linking. We are currently most focused on diepoxybutane, the active form of the prodrug treosulfan, which … Continue reading →