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Welcome to Medical Biochemistry! Thanks to Peter Wirth ’16 for the cover photo! From here you can access valuable course materials, including case studies, powerpoints, and the syllabus (BC362-Syllabus-2016). Choose the Course Materials tab to access powerpoints (remember you must be logged in).

Here is a link to the Online Mendelian Inheritance in Man webpages, which may be very useful when writing your case studies (OMIM). To post your case study, choose  “+ New Post” at the top of the page. This post will automatically appear under the Case Studies tab.

Important News and Updates:

Schedule for final presentations:

Tuesday, Dec 6 Group Topic
1 Lucy, Olivia, and Olivia Pompe disease
2 Jennifer and Chao MCADD
3 Julia and Michaela Maple syrup urine disease
4 Craig and Julian Lysosomal acid lipase deficiency
Thursday, Dec 8
1 Izzy, Melissa, and Tanvir Cobalamin C deficiency
2 Jack, Lauren, and Karolina Wilson’s disease
3 Zoe and Stacey Acute intermittent porphyria
4 Emma and Jane Friedreich ataxia
Friday, Dec 9
A1 Anoush, Allison, Katie Metabolic syndrome
A2 Sara, Jack, and Spencer Chronic Granulomatous Disease
B1 Taylor, Tom, Max Alkaptonuria
B2 DaWon, Maddie, Katy Cushing’s syndrome

Week 12 (week of November 28th): Your metabolic disorder must be approved by midnight tonight. Already taken are metabolic syndrome, cobalamin C deficiency, Pompe disease, Friedrich ataxia, Wilson’s disease, Cushing’s syndrome, MCADD,  chronic granulomatous disease, and acute intermittent porphyria.

Week 10: Bring a calculator to the exam. It can be a graphing calculator. Figures supplied with the exam are Fig 16.1 and Fig 19.6.

Week 8: No discussion meetings on Friday! Instead, we will use our regular Thursday class period for case studies and problem set. No quiz this week!

Answers to Problem Set #7:

  1. a) 3 micromoles (in bridging reaction) b) No additional carbon dioxide formed c) 15 micromoles total

3. a) The label emerges in CO2 in the formation of acetyl CoA from pyruvate. b) After one round of TCA, the label emerges in C-2 and C-3 of oxaloacetate. c) After one round of TCA, the label emerges in C-1 and C-4 of oxaloacetate.

Week 7: Answer to Question 4 of Problem Set #6 follows:

a) C-6 of glucose becomes C-3 of glyceraldehyde 3-phosphate, which becomes C-3 of pyruvate (methyl group). Half the molecules would be labeled.

b) C-3 or C-4 of glucose would be lost during fermentation (C-1 of pyruvate).

Week 6: Don’t forget to bring a calculator to the exam. I will allow you to use any calculator for this exam, although for the final exam, it must be a non-programmable calculator.

Abbreviated solutions to Problem Set #5 are here: ProblemSet5-LimitedAnswers

Lecture schedule has changed. We are skipping Signal Transduction Pathways for now.

Remember that there is no discussion this week. Here is the problem set for next week: ProblemSet6

Week 5: Abbreviated solutions to Problem Set #4 are here: ProblemSet4-LimitedAnswers-2016

Week 4: Abbreviated solutions to Problem Set #3 are here: ProblemSet3-SelectedAnswers

Week 3: Abbreviated solutions to Problem Set #2 are here: ProblemSet2-LimitedAnswers

Discussion on Monday evening!  Below is the schedule and groups for case study presentations. Here is the rubric for these presentations: CaseStudyRubric-BC362.

Date Section A Section B
23-Sep Katie, Allison, Anoush Melissa, Izzy
30-Sep Tomotaka, Tanvir, Olivia Craig, Jennifer, Tom
7-Oct Jack, Spencer, Sara Katy, DaWon, Maddie
28-Oct Michaela, Julia Olivia, Max, and Lucy
3-Nov Zoe, Taylor, Chao Karolina, Lauren, Jane
2-Dec Jack, Julian Emma, Stacey

Week 2 Reminders: No discussion Friday! It is moved to Monday evening at 6:00 in Keyes 105. The quiz is in class on Thursday the 15th on amino acid structures and codes. You must choose your case study group by Friday, or you will be assigned to a group and a date.

For those of you who would like to get a jump on Problem Set #3, here it is: ProblemSet3!