{"id":115,"date":"2018-08-07T14:28:08","date_gmt":"2018-08-07T14:28:08","guid":{"rendered":"http:\/\/web.colby.edu\/noh-lab\/?page_id=115"},"modified":"2024-06-26T12:42:16","modified_gmt":"2024-06-26T16:42:16","slug":"our-research","status":"publish","type":"page","link":"https:\/\/web.colby.edu\/noh-lab\/our-research\/","title":{"rendered":"Our Research"},"content":{"rendered":"<p>&nbsp;<\/p>\n<figure id=\"attachment_164\" aria-describedby=\"caption-attachment-164\" style=\"width: 351px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-164 \" src=\"http:\/\/web.colby.edu\/noh-lab\/files\/2018\/08\/DictyExp-243x300.png\" alt=\"\" width=\"351\" height=\"433\" srcset=\"https:\/\/web.colby.edu\/noh-lab\/files\/2018\/08\/DictyExp-243x300.png 243w, https:\/\/web.colby.edu\/noh-lab\/files\/2018\/08\/DictyExp-768x948.png 768w, https:\/\/web.colby.edu\/noh-lab\/files\/2018\/08\/DictyExp-829x1024.png 829w, https:\/\/web.colby.edu\/noh-lab\/files\/2018\/08\/DictyExp.png 1729w\" sizes=\"(max-width: 351px) 100vw, 351px\" \/><figcaption id=\"caption-attachment-164\" class=\"wp-caption-text\">Our experimental design which involves fluorescent-dyed or labelled&nbsp;<i>D. discoideum<\/i> and <i>Burkholderia<\/i>.<\/figcaption><\/figure>\n<p><em>Dictyostelium discoideum<\/em> is an amoeba whose life cycle includes both single-cell and multicellular stages. The multicellular stage starts when individual amoebas of <em>D.&nbsp;<\/em><em>discoideum<\/em> are starving. They then aggregate to form multicellular fruiting bodies holding amoeba spores.<\/p>\n<p><em>D. discoideum<\/em> hosts three species of bacterial symbionts in the genus <em>Paraburkholderia<\/em> (Brock, Noh et al, 2020). Around one quarter to one third of wild isolated <em>D. discoideum<\/em> are infected with these symbionts. Two of the species (<em>P. bonniea<\/em> and <em>P. hayleyella<\/em>) have evolved reduced genomes that are less than half the size of other <em>Paraburkholderia. <\/em>Their genomes show patterns that indicate adaptations to living in the host environment (Noh et al, 2022).&nbsp;<\/p>\n<p>Our recent and ongoing research projects include (1) testing the fitness consequences of native and novel host-symbiont pairings (Noh et al, 2024); (2) comparing the genomes of amoeba-associated <em>Paraburkholderia<\/em> with other close relatives (Noh et al, 2022); and (3) investigating the functions and origins of candidate symbiosis genes we identified through comparative genomics. &nbsp;<\/p>\n<p>We were <a href=\"https:\/\/www.colby.edu\/magazine\/suegene-noh-investigates-infection-in-amoebas\/\">featured in Colby Magazine online<\/a> to celebrate our grant in 2020.<\/p>\n<p>You can browse the <a href=\"https:\/\/burk.colby.edu\"><em>Paraburkholderia<\/em> symbiont genomes here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Dictyostelium discoideum is an amoeba whose life cycle includes both single-cell and multicellular stages. The multicellular stage starts when individual amoebas of D.&nbsp;discoideum are starving. They then aggregate to form multicellular fruiting bodies holding amoeba spores. D. discoideum hosts three species of bacterial symbionts in the genus Paraburkholderia (Brock, Noh et al, 2020). Around [&hellip;]<\/p>\n","protected":false},"author":7310,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","ngg_post_thumbnail":0,"footnotes":""},"_links":{"self":[{"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/pages\/115"}],"collection":[{"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/users\/7310"}],"replies":[{"embeddable":true,"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/comments?post=115"}],"version-history":[{"count":17,"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/pages\/115\/revisions"}],"predecessor-version":[{"id":432,"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/pages\/115\/revisions\/432"}],"wp:attachment":[{"href":"https:\/\/web.colby.edu\/noh-lab\/wp-json\/wp\/v2\/media?parent=115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}