The answer is a YES!
Susan Elias of Readfield was a member of the USA women’s team which competed in the Tour De Feminin (women’s TdF) in 1989. This race was run concurrently with the men’s race over somewhat shorter distances. Sadly it is no longer held, falling victim to finances.
The link to an Orlando Sentinal article gives some background. Susan was an outstanding runner at UMaine, became bored with running and discovered cycling.